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  Emerging Area of Aging Research:
  Long-lived Animals with
  "Negligible Senescence"



Research 1-8

Research 9-14

Publications on Long Lived Animals

Principal Investigators




Curriculum Vitae

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John C. Guerin
2345 N.E. Sandy Blvd. #25
Portland, OR 97232

(503) 975-4915



Career Positions - Project Management in Biogerontology, Finance and Computer Systems

Professional Positions -

Director, AgelessAnimals, a.k.a. Centenarian Species and Rockfish Project, 1995 - present.

  • DNA Micro-array gene expression, Weis Center for Research, Danville, PA, in collaboration with The Institute for Genomic Research (TIGR), Rockville, MD;
  • Heat shock expression, Neuroscience and Neuropsychology of Aging Program, National Institute on Aging, Bethesda, MD;
  • SOD antioxidant defense changes with age, Weis Center for Research, Danville, PA;
  • Electron transport abnormalities and mDNA mutations, University of Wisconsin-Madison;
  • Turtle Biochemical profiling, Savannah River Ecology Laboratory, in collaboration with Kronos Science, Phoenix, AZ;
  • Mitochondria and nuclear DNA damage,

Linus Pauling Institute, Oregon State University;

  • Complementary DNA library, University of Rochester Medical Center;
  • Rockfish Biochemical profiling, Moss Landing Marine Laboratories, in collaboration with Kronos Science, Phoenix, AZ;
  • Lysosomal markers of intracellular proteolytic activity, Albert Einstein College of Medicine;
  • Age-dependent changes in tocopherol derivatives, Oklahoma Medical Research Foundation;
  • Telomerase expression in rockfish, Christian-Albrechts University in Kiel, Germany;
  • Anion exchange proteins in Alzheimer's disease, University of Nijmegen, the Netherlands;
  • Oxidative damage, Linus Pauling Institute, Oregon State University;
  • Histology, Oregon State University.

Research Associate - Kronos Longevity Research Institute, Phoenix, AZ September 2001 - present. Investigation of the physiology of species characterized by negligible senescence, with focus on rockfish and turtles. Kronos Institute provides logistical, laboratory and research funds management in this non-salaried appointment.

Presentations -
International Association of Biomedical Gerontology (IABG-10), Cambridge England, September 2003 poster presentation. Research results on rockfish SOD (Superoxide dismutase) and Heat Shock gene expression were presented. Initial protocols were reported for an in-process study of DNA Micro-array gene expression.

Buck Institute for Age Research, Novato, CA, October 2001. Seminar presentation: "Emerging Area of Aging Research: Long-Lived Animals with Negligible Senescence".

AGE Conference (American Aging Association), Madison, WI, June 2001 poster presentation. Eight pilot studies presented.

A4M Conference (American Academy of Anti-Aging Medicine), Las Vegas, NV, December 2000 poster presentation. Seven pilot studies presented.

SOSA (Symposium on Organisms with Slow Aging), September 2000 at Andrus Gerontology Center, hosted by Caleb Finch, USC (University of Southern California). Oral presentation of five pilot studies.

AGE Conference June 2000 in Boston, MA (American Aging Association). Oral presentation focused on background of negligible senescence and four pilot studies.

A4M Conference (American Academy of Anti-Aging Medicine), Las Vegas, NV, December 1999 poster presentation. Four pilot studies presented.

WONS 3 (Workshop on Organisms with Negligible Senescence), Andrus Gerontology Center, hosted by Caleb Finch, USC, September 1999. Oral presentation of four pilot studies.

Los Angeles Gerontology Research Group, UCLA, April 1999 (website grg.org). Seminar presentation of two existing pilot studies and one starting project.

WONS 2 (Workshop on Organisms with Negligible Senescence), Andrus Gerontology Center, hosted by Caleb Finch, USC, June 1998. Oral presentation of two pilot studies.

Grants -
HMX, Inc. November 2003. $675 Grant to attend GSA meeting, San Diego, CA.

HMX, Inc. September, 2003. $1,600 Grant to attend IABG-10, Cambridge, England.

Buck Institute for Age Research, October 2001. $300 Honorarium plus $600 expenses paid for presenting Seminar on Negligible Senescence.

A4M (American Academy of Anti-Aging Medicine), September 2001. $1,000 supplemental grant to complete existing pilot studies, prepare full-length grant requests and develop a website for the Centenarian Species and Rockfish Project.

A4M (American Academy of Anti-Aging Medicine), February 2001. $10,000 to continue pilot studies, prepare full-length grant requests, conduct literature search along with personal communication to identify other long-lived animals, and write an article on Negligible Senescence for Anti-Aging Medical News.

Glenn Medical Foundation, November 1997. $10,000 to collect long-lived rockfish frozen tissue and histology samples from offshore near Sitka, Alaska.

Member -

Research Associate, Kronos Longevity Research Institute, September 2001 to present.

Scientific Advisory Board, Legendary Pharmaceuticals, June 2000 to present. (www.legendarypharma.com)

Published -
"Emerging area of aging research: long-lived animals with "negligible senescence", Annals of the New York Academy of Science, June 2004;1019:518-20.

"Long-lived Animals with 'Negligible Senescence'", Anti-Aging Medical News, American Academy of Anti-Aging Medicine, Fall-Winter 2001.

Articles on Centenarian Rockfish Project -
"Researchers are cultivating immortality cells" (Forscher zuchteten Unsterblichkeits-Zellen), by Stefanie Friedhoff, Summer 2004, Gesundheitsbild, Germany. Interviewed for anti-aging article.

"Look where the secret of a long life has hidden" (Guarda dove s'e nascosto il segreto della), by Alice Andreoli, December 19, 2003, La Repubblica (Il Venerdi supplement), Italy. Interviewed for anti-aging article.

"Fishing for Answers to Questions About the Aging Process", by Harvey Black, January 2002, BioScience (www.aibs.org; American Institute of Biological Sciences). Article exclusively on AgelessAnimals.org.

"Centenarian Rockfish", by Vince Cappiello, June 1999, Life Extension Magazine (www.lef.org). Article exclusively on AgelessAnimals.org project.

"Ageless wonders", by Eric Niiler, November 3, 1999, San Diego Union-Tribune, Quest (Science) section. Interviewed in coverage of WONS3 workshop at USC.

Education -
PMP Certification (Project Management Professional), January 2004. Issued by Project Management Institute, Newtown Square, PA.

Lewis and Clark College, B.S., June 1983. Major in Business Administration, GPA 3.82   Phi Kappa Phi National Honor Society and Delta Mu Delta National Business Honorary.   Business courses included Small Business Administration consulting, Financial and Managerial Accounting, Corporate Finance and Statistics. In addition, studied three computer programming languages, advanced economics and writing courses.

Other Career Accomplishments -

Technical Editor - Self-employed free-lancer, Portland, OR 2004 - present.

Staff Accountant (part-time), Accountants, Inc., Portland, OR and San Diego, CA 1996 - 2004. Assignments included Bank Reconciliation, General Ledger Account Reconciliation, Financial Statement analysis, Gift Annuities, and Healthcare Financial utilization statistics.

Accounting Project Manager - Fred Meyer, Inc. Portland, OR June 1989 - February 1995. At this three billion in sales company I reported to the Vice-President / Corporate Controller, and the Accounting Office Manager / Assistant Vice-President. I led financial project teams involving employees from several departments, such at Computer Systems, Store Training, Retail groups, etc. Three technical support positions reported to me directly. Projects included Pharmacy Billing, Check Encoding, Warehouse Accruals, Manufacturer Coupons, Layaway, Money Orders, Bar-coded Gift Certificates, Fred Meyer Credit Card, Debit Card, Flash Sales, Comparable Sales and Wage reporting, Postage Stamps, Mail Routing and Unclaimed Property.

Technical Liaison - Computer Operations, Fred Meyer, Inc. February 1986 - June 1989. Duties included Pharmacy Application, Main Office Wordprocessing, Check Collection, and NCR machines online to Variety and Apparel departments. Wrote procedures and trained operators. Other positions: Documentalist, Data Control Lead.

Computer Operator on IBM 34 and Hewlett Packard 3000 for Earle Palmer Brown Advertising Agency, Bethesda, MD. April 1984 - July 1985. Duties included file and system maintenance, training users, time accounting and trouble shooting user problems.